Publications

2015

Coakley, G., Maizels, R.M. and Buck, A. (2015). Exosomes in host-parasite communication: new answers to old questions. Trends in Parasitology, in press.
 

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Cook, P.C., Owen, H. , Deaton, A., Borger, J.G., Bronw, S., Clouaire, T., Rhys-Jones, G., Jones, L.H., Lundie, R.J., Marley, A.K., Morrison, V.L., Phythian-Adams, A.T., Wachter, E., Webb, L.M., Sutherland, T.E., Thomas, G.D., Grainger J.R., Selfridge, J. McKenzie, A.N.J., Allen, J.E., Fagerholm, S.C., Maizels, R.M., Ivens, A., Bird, A. and MacDonald, A.S. (2015) A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nature Communications 6: 6920

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Farnell, E.J., Tyaghi, N., Ryan, S., Chalmers, I.W., Pinot de Moira, A., Wawrzyniak, J., Jones, F.M., Fitzsimmons, C.M., Tukahebwa, E.M., Furnham, N., Maizels, R.M. and Dunne, D.W. (2015) Known allergen structures predict Schistosoma mansoni IgE binding antigens in human infection.  Frontiers in Immunology 6 : 26 (DOI 10.3389/fimmu.2015.00026)

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Hewitson, J.P., Filbey, K.J., Esser-von Bieren, J., Camberis, M., Schwartz, C., Murray, J., Reynolds, L.A., Blair, N., Robertson, E., Harcus, Y., Boon, L.,  Huang, S.C.-C., Yang, L., Tu, Y., Miller, M.J., Voehringer, D., LeGros, G., Harris, N. and Maizels, R.M. (2015) Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.  PLOS Pathogens 11e1004676 (DOI 10.1371/journal.ppat.1004676).

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Johnston, C.J.C., Robertson, E., Harcus, Y. and Maizels, R.M. (2015) Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products. Journal of Visualized Experiments, 98:e52142

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Johnston, C.J.C., Smyth, D.J., Dresser, D.W. and Maizels, R.M. (2015) TGF-β in tolerance, development and regulation of immunity.   Cellular Immunology  in press

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Mackley, E.C., Houston, S., Marriott, C.L., Halford, E.E., Lucas, B., Cerovic, V., Filbey, K.J., Maizels, R.M., Hepworth, M.R., Sonnenberg, G.F., Milling, S. and Withers, D.R. (2015) CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature Communications 6 : 5862

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McSorley, H.J., Blair, N.F., Robertson, E. and Maizels, R.M. (2015) Suppression of OVA-alum-induced allergy by Heligmosomoides polygyrus is MyD88-, TRIF-, Regulatory T- and B cell-independent, but is associated with reduced Innate Lymphoid Cell activation. Experimental Parasitology 158: 8-17

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Redpath, S.A., van der Werf, N., MacDonald, A.S., Maizels, R.M., Taylor, M.D. (2015) Schistosoma mansoni larvae do not expand or activate Foxp3+ Treg cells during their migratory phase. Infection and Immunity 83: 3881-3889.

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Reynolds, L.A., Finlay, B.B. and Maizels, R.M. (2015) Co-habitation in the intestine - interactions between helminth parasites, bacterial microbiota, and host immunity. Journal of Immunology 195: 4059-4066

 

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Smith, K.A., Filbey, K.J., Reynolds, L.A., Hewitson, J.P., Harcus, Y., Boon, L., Sparwasser, T., Hämmerling, G. and Maizels, R.M. (2015) Low level regulatory T cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunology in press.

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Tyagi, N., Farnell, E.J., Fitzsimmons, C.M., Ryan, S., Tukahebwa, E., Maizels, R.M., Dunne, D.W., Thornton, J.M. and Furnham, N. (2015) Comparisons of allergenic and metazoan parasite proteins: allergy the price of immunity? PLOS Computational Biology 11: e1004546

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2014

Albers, A., Sartono, E., Wahyuni, S., Yazdanbakhsh, M., Maizels, R.M., Klarmann-Schulz, U., Pfarr, K. and Hoerauf, A.  (2014) Real-time PCR detection of the Hhal tandem DNA repeat in pre- and post-patent B. malayi infections: a study in Indonesian transmigrants.  Parasites and Vectors 7: 146

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Buck, A., Coakley, G., Simbari, F., McSorley, H.J., Quintana, J.,Le Bihan, T., Kumar, S., Abreu-Goodger, C., Lear, M., Harcus, Y., Ceroni, A., Babayan, S.A., Blaxter, M.L., Ivens, I. and Maizels, R.M. (2014) Exosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system. Nature Communications, in press

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Filbey KJ, Grainger JR, Smith KA, Boon L, van Rooijen N, Harcus Y, Jenkins S, Hewitson JP and Maizels RM.  (2014) Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.   Immunology and Cell Biology 92: 436-448 

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Hewitson JP, Rückerl D, Harcus Y, Murray J, Webb LM, Babayan SA, Allen JE, Kurniawan A and Maizels RM. (2014) The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria productions in vivo. PLOS Pathogens 10(2): e1003930
 

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Hewitson, J.P. and Maizels, R.M. (2014) Vaccination against helminth parasite infections. Expert Review of Vaccines  13: 473-487

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Johnston CJC, McSorley HJ, Anderton SM, Wigmore SJ and Maizels RM. (2014) Helminths and Immunological Tolerance. Transplantation 97:127-132

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Maizels, R.M. and Gause, W.C.  (2014) Perspective : How helminths go viral.  Science 345: 517-518

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Maizels, R.M. and Withers, D.R. (2014)  MHC-II - a mutual support system for ILCs and T cells ? Immunity 41:174-176

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