Publications

2015

Farnell, E.J., Tyaghi, N., Ryan, S., Chalmers, I.W., Pinot de Moira, A., Wawrzyniak, J., Jones, F.M., Fitzsimmons, C.M., Tukahebwa, E.M., Furnham, N., Maizels, R.M. and Dunne, D.W. (2015) Known allergen structures predict Schistosoma mansoni IgE binding antigens in human infection  Frontiers in Immunology, in press

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Hewitson, J.P., Filbey, K.J., Esser-von Bieren, J., Camberis, M., Schwartz, C., Murray, J., Reynolds, L.A., Blair, N., Robertson, E., Harcus, Y., Boon, L.,  Huang, S.C.-C., Yang, L., Tu, Y., Miller, M.J., Voehringer, D., LeGros, G., Harris, N. and Maizels, R.M. (2015) Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.  PLOS Pathogens in press

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Johnston, C.J.C., Robertson, E., Harcus, Y. and Maizels, R.M. (2015) Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products. Journal of Visualized Experiments, in press

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Mackley, E.C., Houston, S., Marriott, C.L., Halford, E.E., Lucas, B., Cerovic, V., Filbey, K.J., Maizels, R.M., Hepworth, M.R., Sonnenberg, G.F., Milling, S. and Withers, D.R. (2015) CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature Communications, in press

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2014

Albers, A., Sartono, E., Wahyuni, S., Yazdanbakhsh, M., Maizels, R.M., Klarmann-Schulz, U., Pfarr, K. and Hoerauf, A.  (2014) Real-time PCR detection of the Hhal tandem DNA repeat in pre- and post-patent B. malayi infections: a study in Indonesian transmigrants.  Parasites and Vectors 7: 146

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Buck, A., Coakley, G., Simbari, F., McSorley, H.J., Quintana, J.,Le Bihan, T., Kumar, S., Abreu-Goodger, C., Lear, M., Harcus, Y., Ceroni, A., Babayan, S.A., Blaxter, M.L., Ivens, I. and Maizels, R.M. (2014) Exosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system. Nature Communications, in press

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Filbey KJ, Grainger JR, Smith KA, Boon L, van Rooijen N, Harcus Y, Jenkins S, Hewitson JP and Maizels RM.  (2014) Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.   Immunology and Cell Biology 92: 436-448 

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Hewitson JP, Rückerl D, Harcus Y, Murray J, Webb LM, Babayan SA, Allen JE, Kurniawan A and Maizels RM. (2014) The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria productions in vivo. PLOS Pathogens 10(2): e1003930
 

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Hewitson, J.P. and Maizels, R.M. (2014) Vaccination against helminth parasite infections. Expert Review of Vaccines  13: 473-487

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Johnston CJC, McSorley HJ, Anderton SM, Wigmore SJ and Maizels RM. (2014) Helminths and Immunological Tolerance. Transplantation 97:127-132

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Maizels, R.M. and Gause, W.C.  (2014) Perspective : How helminths go viral.  Science 345: 517-518

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Maizels, R.M. and Withers, D.R. (2014)  MHC-II - a mutual support system for ILCs and T cells ? Immunity 41:174-176

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Maizels, R.M., McSorley, H.J. and Smyth, D.J. (2014). Helminths in the hygiene hypothesis - sooner or later?  Clin Exp Immunol. 177: 38-46

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McSorley HJ, Blair NF, Smith KA, McKenzie ANJ and Maizels RM. (2014) Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunology 7: 1068-1078

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Reynolds, L.A., Harcus, Y., Smith, K.A., Webb, L.M., Hewitson, J.P., Ross, E.A., Brown, S., Uematsu, S., Akira, S., Gray, M., Gray, D., MacDonald, A.S., Cunningham, A. and Maizels, R.M. (2014) MyD88 signaling inhibits protective immunity to the gastrointestinal helminth  parasite Heligmosomoides polygyrus. Journal of Immunology 193: 2984-2993

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Reynolds, L.A., Smith, K.A., Filbey,  K.J., Harcus, Y., Hewitson, J.P., Yebra, M.  and Maizels, R.M. (2014) Commensal-pathogen interactions in the intestinal tract: Lactobacilli promote infection with, and are promoted by, helminth parasites. Gut Microbes 5:10-9

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Smith, K.A., and Maizels, R.M. (2013) IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg cell phenotype in vivoEuropean Journal of Immunology 44: 150-161

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Sotillo, J., Sanchez-Flores, A., Cantacessi, C., Harcus, Y., Pickering, D. Bouchery, T., Camberis, M., S.-C., Giacomin, P., Mulvenna, J., Mitreva, M., Berriman, M., Le Gros, G., Maizels, R.M., Loukas, A. (2014) Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensisMolecular and Cellular Proteomics 13: 2736-2751

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Sutherland, T.R., Logan, N., Rückerl, D., Humbles, A.A., Stockinger, B., Maizels, R.M. and Allen, J.E. (2014) Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage. Nature Immunology 15: 1116-1125.

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2013

Hewitson, J.P., Ivens, A.C., Harcus, Y., Filbey, K.J., McSorley, H.J., Murray, J., Bridgett, S., Ashford, D., Dowle, A.A. and Maizels, R.M. (2013) Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity. PLoS Pathogens 9(8): e1003492

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