Previous Publications

Publications, 2010

Artis, D. and Maizels, R.M. (2010) Acquired Immunity to Helminths. In Immunology of Infectious Diseases (Eds, Kaufmann, S., Rouse, B., and Sacks, D.) 

Barnwell, E.M., van Deursen, F.J., Jeacock, L., Smith, K.A., Maizels, R.M., Alvaro Acosta-Serrano, A., and Matthews, K. (2010) Developmental regulation and extracellular release of a VSG expression site-associated gene product from Trypanosoma brucei bloodstream forms. Journal of Cell Science in press

Belkaid, Y., Liesenfield, O. and Maizels, R.M.  (2010)  Induction and control of regulatory T cells in the GI tract: consequences for local and peripheral immune responses. Clinical and Experimental Immunology 160:35-41

Grainger, J.R., Smith, K.A., Hewitson, J.P., McSorley, H.J., Harcus, Y., Filbey, K.J., Finney, C.A.M., Greenwood, E.J.D., Knox, D.P., Wilson, M.S., Belkaid, Y., Rudensky, A.Y., and Maizels, R.M. (2010) Helminth secretions induce de novo T cell Foxp3+ expression and regulatory function through the TGF- pathway. Journal of Experimental Medicine, in press

McSorley, H.J., Grainger, J.R., Harcus, Y.M., Murray, J.,  Nisbet, A., Knox, D. P. and Maizels, R.M. (2010)  daf-7-related TGF- homologues from trichostrongyloid nematodes show contrasting life cycle expression patterns. Parasitology 137:159-171

Milner, T., Reilly, L., Nausch, N., Midzi, N., Mduluza, T., Maizels, R.M. and Mutapi, F. (2010) Circulating cytokine and antibody levels in human Schistosoma haematobium: IL-5 and IL-10 levels depend on age and infection status. Parasite Immunology in press

Nisbet, A.J., Bell, N., McNeilly, T.N., Knox, D.P., Maizels, R.M., Meikle, L.I., Wildblood, L.A. and Matthews, J.B. (2010) A macrophage migration inhibitory factor-like tautomerase from Teladorsagia circumcincta (Nematoda: Strongylida). Parasite Immunology 7: 503-511.

Phythian-Adams, A.T., Cook, P.C., Lundie, R.J., Jones, L.H., Smith, K.A., Barr, T.A., Hochweller, K., Anderton, S.M., Hämmerling, G.J., Maizels, R.M. and MacDonald, A.S. (2010) CD11c depletion severely disrupts Th2 induction and development in vivo  Journal of Experimental Medicine, in press

Wammes, L.J., Hamid, F., Wiria, A.E., de Gier, B., Sartono, E., Maizels, R.M., Luty, A.J., Fillié, Y.E., Brice, G.T., Supali, T., Smits, H.H. and Yazdanbakhsh, M.  (2010) Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum. European Journal of Immunology 40:437-442

Wilson, M.S., Taylor, M.D., O’Gorman, M., Balic, A., Barr, T.A., Filbey, K., Anderton, S.M. and Maizels, R.M. (2010). Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. European Journal of Immunology 40: 1682–1696

Publications, 2009

Balic, A., Smith, K.A., Harcus, Y. and Maizels, R. M. (2009) Dynamics of CD11c+ dendritic cell subsets  in lymph nodes draining the site of intestinal nematode infection. Immunology Letters, 127: 68-75

Fernández, C. and Maizels, R.M. (2009) Generating EST libraries: trans-spliced cDNAs. Expressed Sequence Tags (ESTs): Generation and Analaysis (Ed Parkinson, J.) Humana Press, 24pp. Methods in Molecular Biology 533:1-27

González, S., Fló, M. Margenat, M., Durán, R., González-Sapienza, G., Graña, M., Parkinson, J., Maizels, R.M., Salinas, G.,  Álvarez, B. and Fernández, C. (2009).  A family of diverse Kunitz inhibitors from Echinococcus granulosus involved in host-parasite cross-talk in Echinococcosis.  PLOS One 4(9): e7009 (14pp)

Harcus, Y.M., Nicoll, G., Murray, J., Filbey, K., Gomez-Escobar, N., and Maizels, R.M. (2009)  C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Parasitology International 58: 461-470

Hewitson, J.P., Grainger, J.R. and Maizels, R.M. (2009) Helminth immunoregulation – the role of parasite secreted proteins in modulating host immunity. Molecular and Biochemical Parasitology 167 : 1-11

Maizels, R.M. (2009) Exploring the immunology of parasitism: from surface antigens to the hygiene hypothesis. Parasitology, 136: 1549-156210. 

Maizels, R.M.  (2009)  Parasite immunomodulation and polymorphisms of the immune system. Journal of Biology 8: 62 (4 pp)

Maizels, R.M., Pearce, E.J., Artis, D,  Yazdanbakhsh, M. and Wynn, T.A. (2009)  Regulation of pathology and immunity in helminth infections. Journal of Experimental Medicine  206: 2059-2066

Maizels, R.M. and Weidermann, U. (2009) Immunoregulation by microbes and parasites in the control of allergy and autoimmunity.  In “The Hygiene Hypothesis and Darwinian Medicine” (Progress in Inflammation Research) ed. G.A.W. Rook, Birkhäuser Publishing, Basel, Switzerland,  pp 45-75

Perona-Wright, G., Jenkins, S.J., O’Connor, R.A., Zienkiewicz, D., McSorley, H.J., Maizels, R.M., Anderton, S. M. and MacDonald, A.S.  (2009) A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.  Journal of Immunology 182 : 2808-2815

Prieto-Lafuente, L., Gregory, W.F., Allen, J.E. and Maizels, R.M. (2009) MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages. Journal of Leucocyte Biology 85: 844-854

Smith, H., Holland, C., Taylor, M., Magnaval, J.-F., Schantz, P. & Maizels, R.M. (2009) How common is human toxocariasis? Towards standardising our knowledge.  Trends in Parasitology 25: 182-188

Sutherland, T., Maizels, R.M. and Allen, J.E.  (2009)  Chitinases and chitinase-like proteins: potential therapeutic targets for treatment of Th2allergies. Clinical and Experimental Allergy 39: 943-955

Taylor, M.D., van der Werf, N., Harris, A., Graham, A.L., Bain, O., Allen, J.E. and Maizels, R.M. (2009)Early recruitment of natural CD4+Foxp3+ regulatory T cells by infective larvae determines the outcome of filarial infection.  European Journal of Immunology 39: 192-206 

Publications, 2008

Callister, D.M., Winter, A.W., Page, A.P. and Maizels, R.M. (2008) Homologous noncoding regions from four distinct  abundant novel transcript genes of Toxocara canis  are implicated in the control of gene expression. Molecular and Biochemical Parasitology 162 : 60-70

Gregory, W.F. and Maizels, R.M. (2008) Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. International Journal of Biochemistry and Cell Biology 40 :1389–1398

Hewitson, J.P., Harcus, Y.M, Curwen, R.S., Dowle, A., Atmadja, A.K., Ashton, P., Wilson, A., and Maizels, R.M.  (2008)  The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.  Molecular and Biochemical Parasitology 160 : 8-21

MacDonald, A.S. and Maizels, R.M. (2008) Alarming dendritic cells for Th2 induction.  Journal of Experimental Medicine 205 : 13-17  

McSorley, H., Harcus, Y., Murray, J., Taylor, M.D. and Maizels, R.M.  (2008) Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite, Brugia malayi.  Journal of Immunology 181 : 6456-6466

Maizels, R.M., Gomez-Escobar, N., Prieto-Lafuente, L., Murray, J. and Aebischer, T.
(2008) Expression of helminth genes in Leishmania: an experimental transfection system to test immunological function.  Parasite Immunology 30 :195-201

Maizels, R.M. and Yazdanbakhsh, M. (2008) T cell regulation in helminth parasite infections : implications for inflammatory diseases. In T Cell Regulation in Allergy, Asthma and Atopic Skin Diseases (Ed. Blaser, K.; Karger Publishers, Basel, Switzerland) Chemical Immunology and Allergy 94 : 112-123

Mutapi, F., Burchmore, R.,  Mduluza, T.,  Midzi, N., Turner, C.M. & Maizels, R.M. (2008) Age- and intensity-related shifts in recognition of defined protein antigens in a Schistosome-exposed population.  Journal of Infectious Diseases 198 : 167-175    

Publications, 2007

Finney, C.A.M., Taylor, M.D., Wilson, M.S. and Maizels, R.M. (2007)  Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection.  European Journal of Immunology 37 : 1874-1886

Maizels, R.M. (2007)  Regulation of the immune response in metazoan parasite infections.  Novartis Foundation Symposium 281  Decoding the Genomic Control of Immune Reactions.  pp 192-204, discussion 204-9  

Mutapi, F., Winborn, G., Midzi, N, Taylor, M., Mduluza, T. and Maizels, R. M.(2007) Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting age profiles for IFN-g, IL-4, IL-5 and IL-10 with age.  BMC Infectious Diseases 7: 139

Schabussova, I., Amer, H.. van Die, I., Kosma, P and Maizels, R.M. (2007) O- methylated glycans from Toxocara are specific targets for antibody binding in human and animal infections.  International Journal for Parasitology 37: 97-109

Taylor, M.D., Harris, A., Babayan, S., Bain, O., Allen, J.E. and Maizels, R.M. (2007)
CTLA-4 and CD4+CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo.  Journal of Immunology 179 : 4626-4634 

Publications, 2006

Balic, A., Harcus, Y., Taylor, M.D., Brombacher, F. and Maizels, R.M. (2006) IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance. International Immunology 18 : 1421-1431

Bulgheresi, S., Schabussova, I., Chen, T., Mullin, N.P., Maizels R.M. & Ott, J.A. (2006) A new C-type lectin similar to the human immunoreceptor DC-SIGN mediates symbiont acquisition by a marine nematode. Applied and Environmental Microbiology 72 : 2950-2956

Maizels, R.M., Callister, D.M., Schabussova, I., and Nicoll, G. (2006) Molecular biology and immunology of Toxocara canis. In Toxocara the Enigmatic Parasite, (Eds, Holland, C., and Smith, H.V.) CABI. pp 3-17.

Mutapi, F., Mduluza, T., Gomez-Escobar, N., Gregory, W.F., Fernandez, C., Midzi, N. and Maizels, R.M. (2006) Immuno-epidemiology of Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden. BMC Infectious Diseases 6 : 96; 1-11

Taylor, M.D., Harris, A., Nair, M.G., Maizels, R.M. and Allen, J.E. (2006) F4/80+ alternatively activated macrophages control CD4+ T cell hypo-responsiveness at sites peripheral to filarial infection. Journal of Immunology 176 : 6918-6927

Wilson, M.S. and Maizels, R.M. (2006) Regulatory T cells induced by parasites and the modulation of allergic responses. Parasites and Allergy, eds., Capron, M. and Trottein, F., Chemical Immunology and Allergy 90 : 176-195, S. Karger AG, Basel.

Publications, 2005

Gomez-Escobar, N., Bennett, C., Prieto-Lafuente, L., Aebischer, T., Blackburn, C.C. and Maizels, R.M. (2005) Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune function. BMC Biology 3: 8; 1-16

Holland, M.J., Harcus, Y.M., Balic, A. and Maizels, R.M. (2005) Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related ligands. Immunology Letters 96 : 93-101

Maizels, R.M. (2005) Infections and allergy : helmindownload pdf fileths, hygiene and host immune regulation. Current Opinion in Immunology 17 : 656-661

Mutapi, F., Burchmore, R., Mduluza, T., Foucher, A., Harcus, Y., Nicoll, G., Midzi, N., Turner, C.M. and Maizels, R.M. (2005) Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined peptide antigens. Journal of Infectious Diseases 192 : 1108-1118

Murray, J., Manoury, B., Balic, A., Watts, C. and Maizels, R.M. (2005) Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from C.elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Molecular and Biochemical Parasitology 139:197-203

Noordin, R., Smith, H.V., Mohamed, S., Maizels, R.M. and Fong, M.Y. (2005) Comparison of IgG-ELISA and IgG4-ELISA for Toxocara serodiagnosis. Acta Tropica 93: 57-62

Nair, M., Gallagher, I., Taylor, M., Loke, P., Coulson, P.S., Wilson, R.A., Maizels, R.M. and Allen, J.E. (2005). Chitinase and FIZZ family members (CHAFFs) are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen presenting cells. Infection and Immunity 73 : 385-394

Pinelli, E., Withagen, C., Fonville, M., Verlaan, A., Dormans, J., van Loveren, H., Nicoll, G., Maizels, R.M. and van der Giessen, J. (2005) Persistent airway hyperresponsiveness and inflammation in Toxocara canis infected BALB/c mice. Clinical and Experimental Allergy 35: 826-832

Taylor, M.D., LeGoff, L., Harris, A., Malone, E., Allen, J.E. and Maizdownload pdf fileels, R.M. (2005) Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology 175 : 4924-4933

Wilson, M S., Taylor, M., Balic, A., Finney, C.A.M., Lamb, J.R. and Maizels, R.M. (2005) Suppression of allergic airway inflammation by helminth-induced regulatory T cells. Journal of Experimental Medicine 202: 1199-1212.

Publications, 2004

Balic, A., Harcus, Y., Holland, M.J., and Maizels, R.M. (2004) Selective maturation of dendritic cells by Nippostrongylus brasiliensis secreted proteins drives T helper type 2 immune responses. European Journal of Immunology 34: 3047-3059 FACULTY of 1000 EVALUATION

Fischer, P. Supali, T. and Maizels, R.M. (2004) Lymphatic filariasis due to Brugia timori and its prospects for elimination. Trends in Parasitology 20: 351-355.

Freire, T., Fernández, C., Chalar, C., Maizels, R.M., Alzari, P., Osinaga, E. and Robello, C. (2004) Characterization of a UDP-N-acetyl-D-galactosamine: polypeptide N-acetyl-galactosaminyl-transferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus. Biochemical Journal 382 : 501-510

Harcus, Y.M., Parkinson, J., Fernández, C., Daub, J., Selkirk, M.E., Blaxter, M.L. and Maizels, R.M. (2004) Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites. Genome Biology 5: R39.1-15

Maizels, R.M. and Balic, A. (2004) Resistance to helminth infection: the case for IL-5-dependent mechanisms. Journal of Infectious Diseases 190 : 427-429

Maizels, R.M., Balic, A., Gomez-Escobar, N., Nair, M., Taylor, M. and Allen, J.E. (2004) Helminth parasites – masters of regulation. Immunological Reviews 201: 89-116

Salinas, G., Selkirk, M.E., Chalar, C., Maizels, R.M. and Fernández, C. (2004) Linked thioredoxin-glutathione systems in Platyhelminths. Trends in Parasitology 20: 340-346.

Wilson, M.S. and Maizels, R.M. (2004) Regulation of allergy and autoimmunity in helminth infection. Clinical Reviews in Allergy and Immunology 26: 35-50

Publications, 2003

Maizels, R. M. and Yazdanbakhsh, M. (2003) Immune regulation by helminth parasites - cellular and molecular mechanisms. Nature Reviews Immunology 3: 733-744 FACULTY of 1000 EVALUATION

Maizels, R. M. and Selkirk, M.E. (2003) Editors: Molecular and Cellular Biology of Helminth Parasites. International Journal of Parasitology 33: 1127-1302

Noordin, R., Shenoy, R.K., Nutman, T.B., Weiss, N. Gilmour, K., Maizels, R.M., Yazdanbakhsh, M. and Sartono, E. (2003) Multicenter laboratory evaluation of Brugia Rapid dipstick test for detection of Brugian filariasis. Tropical Medicine and International Health 10 : 895-900.

Publications, 2002

Fernandez, C., Gregory, W.F., Loke, P., and Maizels, R.M. (2002) Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide sequences. Molecular and Biochemical Parasitology 122: 171-180

LoVerde, P.T., Li, C., Maizels, R.M., Geary, T.G. and Colley, D.G. (2002) Molecular helminthology: an integrated approach. American Journal of Tropical Medicine and Hygiene 66: 346-347

Maizels, R.M. and Atmadja, A.K. (2002) Variation and polymorphism in helminth parasites. Parasitology 125: S25-S37

Zang, X., Taylor, P., Meyer, D.J., Wang, J.M., Scott, A.L., Walkinshaw, M.D. and Maizels, R.M. (2002) Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity and crystal structure. Journal of Biological Chemistry 277 : 44261-44267

Gomez-Escobar, N., Gregory, W.F., Britton, C., Murray, L., Corton, C., Hall, N., Daub, J., Blaxter, M.L. and Maizels, R.M. (2002) Abundant Larval Transcript (alt) -1 and -2 genes from Brugia malayi : diversity of genomic environments but conservation of 5' promoter sequences functional in Caenorhabditis elegans. Molecular and Biochemical Parasitology 125: 59-71

Publications 2001

Doedens, A., Loukas, A.C. and Maizels R.M. (2001) MUC-5 : a new mucin gene from Toxocara canis Acta Tropica, 79 : 211-217

Falcone, F.H., Loke, P., Zang, X.X., MacDonald, A.S., Maizels, R.M. and Allen, J.E. (2001) A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection. Journal of Immunology 167: 5348-5354

Falcone, F., Rossi, A., Sharkey, R., Brown, A.P., Pritchard, D.I. and Maizels, R.M. (2001) Ascaris suum derived products induce neutrophil activation via a putative novel G-protein coupled receptor that interacts with the IL-8 receptor pathway. Infection and Immunity 69 : 4007-4018

Maizels, R.M., Blaxter, M.L. and Scott, A.L. (2001) Immunogenomics of filariasis: genes and gene families implicated in immune evasion and protective immunity. Parasite Immunology  69 : 4007-4018

Maizels, R. M., Gomez, N., Gregory, W.F., Murray, J., and Zang, X.X. (2001). Immune evasion genes from filarial nematodes. International Journal of Parasitology 31: 889-898

Maizels, R.M. and Loukas, A. (2001) The surface and secreted antigens of Toxocara canis: genes, protein structure and function. In Parasitic Nematodes - Molecular Biology, Biochemistry and Immunology, Eds M. W. Kennedy and W. Harnett, CABI Publishing, Wallingford (ISBN 0 85199 423 7) pp 229-246

Manoury, B., Gregory, W.F., Maizels, R.M. and Watts, C. (2001) CPI-2, a cystatin homologue secreted by the filarial parasite Brugia malayi inhibits class II MHC-restricted antigen processing. Current Biology, 11: 447-451

Murray, J., Gregory, W.F., Atmadja, A.K., Gomez-Escobar, N. and Maizels, R.M. (2001) Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins. Molecular and Biochemical Parasitology 118: 89-96

Terhell, A.J., Haarbrink, M., Abadi, K., Syafruddin, Maizels, R.M., Yazdanbakhsh, M. and Sartono, E. (2001) Adults acquire filarial infection more rapidly than children: a study in Indonesian transmigrants. Parasitology 122 : 633-640

Yazdanbakhsh, M., van den Biggelaar, A. and Maizels, R.M. (2001) Infections and allergy: immuno-regulation in chronic helminth parasite infections may explain reduced levels of atopy in the face of Th2 responses. Trends in Immunology 22 : 372-377

Zang, X. and Maizels, R.M. (2001) Serine proteinase inhibitors from nematodes and the arms race between host and pathogen. Trends in Biochemical Sciences 26:191-197

Publications 2000

Falcone, F., Tetteh, K.K.A., Hunt, P., Blaxter, M.L. Loukas, A. and Maizels, R.M. (2000) The new subfamily of cathepsin Z-like protease genes includes Tc-cpz-1, a cysteine protease gene expressed in Toxocara canis adults and infective stage larvae. Experimental Parasitology 94: 201-207

Gomez-Escobar, N., Gregory, W.F. and Maizels, R.M. (2000) Identification of Bm-tgh-2, a filarial nematode homolog of C.elegans daf-7 and human TGF-b, expressed in microfilarial and adult stages of Brugia malayi. Infection and Immunity 68 : 6402-6410

Gregory, W.F., Atmadja, A.K., Allen, J.E. and Maizels, R.M. (2000) The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infection and Immunity 68: 4174-4179

Holland, M.J., Harcus, Y.M., Riches, P.L. and Maizels, R.M. (2000) Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses. European Journal of Immunology 30: 1977-1987

Loke, P., MacDonald, A.S., Robb, A., Maizels, R.M. and Allen, J.E. (2000) Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell to cell contact. European Journal of Immunology 30: 2669-2678

Loukas, A. and Maizels, R.M. (2000) Helminth C-type lectins and host-parasite interactions. Parasitology Today 16 : 333-339

Loukas, A., Doedens, A., Hintz, M. and Maizels, R.M. (2000) Identification of a new C-type lectin, TES-70, secreted by infective larvae of Toxocara canis, which binds to host endothelial cells. Parasitology 121: 545-554

Loukas, A.C., Hintz, M., Linder, D., Mullin, N.P., Parkinson, J., Tetteh, K.K.A. and Maizels R.M. (2000) A family of secreted mucins from the parasitic nematode Toxocara canis bear diverse mucin domains but share similar flanking six-cysteine (SXC) repeat motifs. Journal of Biological Chemistry 275 : 39600-39607

Maizels, R.M., Allen, J.E. and Yazdanbakhsh, M. (2000) Immunology of Lymphatic Filariasis : Current Controversies. In Lymphatic Filariasis (ed. Nutman T.B.), Imperial College Press, pp 217-243

Maizels, R.M., Tetteh, K.K.A. and Loukas, A. (2000) Toxocara canis : Genes expressed by the arrested infective larval stage of a parasitic nematode. International Journal of Parasitology 30: 495-508

Zang, X.X., Kurniawan, A.K., Gray, P., Allen, J.E., Gray, C., Lawrence, R.A., Yazdanbakhsh, M. and Maizels, R.M. (2000) The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong but short-lived immune responses in mice and humans. Journal of Immunology 165 : 5161-5169